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UID:20250803T052452EDT-1312nEc6t5@132.216.98.100
DTSTAMP:20250803T092452Z
DESCRIPTION:The primary focus of my research over the past 25 years has bee
 n to understand the structure and function of the cerebral circulation und
 er normal and pathological conditions\, and how cerebrovascular dysfunctio
 n can promote brain injury. We are focused on understanding mechanisms by 
 which different segments of the vasculature respond to ischemia and reperf
 usion and have harnessed this heterogeneity to provide therapeutic targets
 . More recently\, we have focused on stroke co-morbidities such as hyperte
 nsion and how the cerebrovasculature responds functionally during both isc
 hemia to limit collateral perfusion\, and during reperfusion to promote bl
 ood-brain barrier disruption and impair perfusion. We are one of the few l
 abs that have the expertise to study the microvessels in the brain isolate
 d and pressurized and have provided important insight into ischemia and re
 perfusion-induced changes in brain hippocampal and parenchymal arterioles 
 and leptomeningeal anastomoses (pial collaterals). We also have a long-sta
 nding interest in how pregnancy and preeclampsia affect the blood-brain ba
 rrier and cerebral blood flow autoregulation in ways that promote the neur
 ological complications of preeclampsia\, including seizure (eclampsia) and
  early-onset cognitive decline. We have determined mechanisms by which cir
 culating factors in pregnancy and preeclampsia cause edema formation and p
 romote seizure. We have recently combined our interest and expertise in pr
 egnancy adaptation and ischemic stroke to study how preeclampsia worsens s
 troke outcome. Lastly\, we have also begun to study how the adverse intrau
 terine environment of preeclampsia affects the cerebral circulation of off
 spring that predisposes them to early-onset hypertension and stroke.\n\nTh
 is seminar will take place in-person and online (details in attached poste
 r below). All are welcome!\n\n \n
DTSTART:20231117T160000Z
DTEND:20231117T170000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Physiology Seminar: Marilyn J. Cipolla 'Vascular Biology in Health 
 and Disease through the Lifespan'
URL:/physiology/channels/event/physiology-seminar-mari
 lyn-j-cipolla-vascular-biology-health-and-disease-through-lifespan-352618
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