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UID:20250802T160450EDT-87350vlMkR@132.216.98.100
DTSTAMP:20250802T200450Z
DESCRIPTION:Physical forces are critical for the development\, maintenance\
 , and adaptation of various tissues in the body including bone. Bone adapt
 s to mechanical loads through actions of bone cells: osteoclasts that spec
 ialize in bone resorption\; osteoblasts that produce bone\; and osteocytes
  embedded in bone matrix that sense mechanical forces and coordinate bone 
 adaptation. ATP is a ubiquitous intracellular molecule critical for cellul
 ar bioenergetics\, which is also one of the first signals released from bo
 ne cells that experience mechanical stimulation. Extracellular ATP is degr
 aded by ecto-ATPases to form ADP and eventually adenosine. I will discuss 
 our studies investigating how spatiotemporal signals provided by extracell
 ular ATP and ADP may encode the information regarding severity\, scale and
  proximity of the mechanical stimulus\, allowing for a well-choreographed 
 tissue responses to physical forces.\n\nThis seminar will take place in-pe
 rson and online (details in attached poster below). All are welcome!\n
DTSTART:20231027T150000Z
DTEND:20231027T150000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Physiology Seminar: Dr. Svetlana Komarova 'The role of extracellula
 r ATP and its derivatives in responses of bone cells to physical forces' '
URL:/physiology/channels/event/physiology-seminar-dr-s
 vetlana-komarova-role-extracellular-atp-and-its-derivatives-responses-bone
 -351559
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