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UID:20250808T062935EDT-2244Uo18lK@132.216.98.100
DTSTAMP:20250808T102935Z
DESCRIPTION:ABSTRACT:\n\nMechanotransduction\, the conversion of mechanical
  stimuli into biochemical signals\, is facilitated by numerous macromolecu
 les\, ion channels\, and protein complexes within the cell. The nucleus it
 self also serves as a mechanosensor\, integrating cytoskeletal and externa
 l stresses. In my research\, we have found that nuclear strain mechanosens
 ing appears to be a master control parameter for the regulation of Yes Ass
 ociated Protein (YAP). In this talk\, I will describe the biophysical regu
 lation of YAP activity due to nuclear compression\, how this is modulated 
 by the structural protein Lamin A/C\, and discuss some of the far-reaching
  applications from stem cell differentiation\, to cancer and cellular agin
 g.\n\n \n\nThis seminar will take place in-person and online (details in a
 ttached poster below)\n
DTSTART:20230317T150000Z
DTEND:20230317T160000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Physiology Seminar by Dr. Allen J. Ehrlicher: ' Under pressure: com
 pression-mediated nuclear mechanotransduction'
URL:/physiology/channels/event/physiology-seminar-dr-a
 llen-j-ehrlicher-under-pressure-compression-mediated-nuclear-346225
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