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UID:20250803T160412EDT-6617UAnIsh@132.216.98.100
DTSTAMP:20250803T200412Z
DESCRIPTION: \n\nTo personalize medicine\, we must be able to model disease
  on a patient-specific basis. We have enrolled >200 patients diagnosed wit
 h dilated cardiomyopathy (DCM) of diverse etiologies and at various stages
  of disease progression who currently take a wide array of standard heart 
 failure medications. Using peripheral blood mononuclear cells (PBMCs)\, we
  generate induced pluripotent stem cell (iPSC) lines and derive cardiovasc
 ular-relevant cells from them. Experimental evidence suggests that cellula
 r signalling networks or signalling “hubs” that control cell function and 
 fate are cell- and tissue-type specific. Each signalling “hub” is also inf
 luenced by a patient’s personalized genetic profile. Spatiotemporal aspect
 s of signalling are thus determined by how these signalling hubs are alter
 ed in disease. Considering that DCM is largely characterized as ventricula
 r dilation with systolic dysfunction\, we anticipate that the underlying p
 athophysiological mechanisms leading to this state are not unique in each 
 patient but recur in several patients. We believe that the systematic mapp
 ing of signalling outcomes in healthy versus DCM patient-derived iPSC-CMs 
 will help identify of a core number of deregulated pathways and will facil
 itate our understanding of the influence of cell context on disease evolut
 ion. Our iPSC-based platforms give us the means to study these events in m
 ultiple cell types relevant to the cardiovascular system in health and dis
 ease right down to the single cell level using resonance energy transfer-b
 ased biosensors. Our working hypothesis is that the molecular underpinning
 s of dilated cardiomyopathy can be clustered into a finite number of pheno
 typic and signalling subtypes. Our strategy is to leverage patient-derived
  cardiomyocytes to understand how to approach survival and function of the
 se cells in response to currently used therapies.\n\nThis seminar will tak
 e place both in-person and online. Details in attached poster\n
DTSTART:20230203T160000Z
DTEND:20230203T170000Z
LOCATION:room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Physiology Seminar: Disease-in-a-dish modelling using iPSCs
URL:/physiology/channels/event/physiology-seminar-dise
 ase-dish-modelling-using-ipscs-345148
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