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UID:20250807T225413EDT-6769IEWz1m@132.216.98.100
DTSTAMP:20250808T025413Z
DESCRIPTION:Mural cells known as pericytes may play a role brain blood flow
  at the capillary level\, including in neurovascular coupling and vasomoti
 on. However\, their ability to contract or dilate capillaries is currently
  debated. Recent morphological analysis suggests there are at least two di
 stinct populations of pericytes\, ensheathing and capillary pericytes\, at
  different points in the vascular tree. Our research aims to disentangle t
 he roles of these pericyte populations in brain hemodynamics by studying t
 heir calcium signalling mechanisms. We use transgenic mice with expression
  of genetically encoded calcium indicators (GCaMP6s and RCaMP1.07) in diff
 erent pericyte populations to visualize intracellular calcium signals via 
 two photon microscopy in brain slices and in vivo. By targeting different 
 ion channel pathways pharmacologically\, we found that ensheathing and cap
 illary pericytes have different basal calcium pathways and different roles
  in hemodynamics at rest and during sensory stimulation to evoke neurovasc
 ular coupling. This work is feeding into longitudinal studies of pericytes
  in aging and Alzheimer’s Disease\, since blood flow changes may contribut
 e to cognitive decline and pericytes may serve as a potential therapeutic 
 target.\n\nThis seminar will be given online via Zoom. Details in attached
  poster.\n
DTSTART:20220422T150000Z
DTEND:20220422T160000Z
SUMMARY:Online seminar: Calcium ion channels in brain pericyte signalling a
 nd blood flow control
URL:/physiology/channels/event/online-seminar-calcium-
 ion-channels-brain-pericyte-signalling-and-blood-flow-control-337486
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