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UID:20250810T194533EDT-3262rJ0vVU@132.216.98.100
DTSTAMP:20250810T234533Z
DESCRIPTION:Intestinal organoids capture essential features of the intestin
 al epithelium such as folding of the crypt\, spatial compartmentalization 
 of different cell types\, and cellular movements from crypt to villus-like
  domains. Each of these processes and their coordination in time and space
  requires patterned physical forces that are currently unknown. In this st
 udy\, we map the three-dimensional cell-ECM and cell-cell forces in mouse 
 intestinal organoids grown on soft hydrogels. We show that these organoids
  exhibit a non-monotonic stress distribution that defines mechanical and f
 unctional compartments. The stem cell compartment pushes the ECM and folds
  through apical constriction\, whereas the transit amplifying zone pulls t
 he ECM and elongates through basal constriction. Tension measurements esta
 blish that the transit amplifying zone isolates mechanically the stem cell
  compartment and the villus-like domain. A 3D vertex model shows that the 
 shape and force distribution of the crypt can be largely explained by cell
  surface tensions following the measured apical and basal actomyosin densi
 ty. Finally\, we show that cells are pulled out of the crypt along a gradi
 ent of increasing tension\, rather than pushed by a compressive stress dow
 nstream of mitotic pressure as previously assumed. Our study unveils how p
 atterned forces enable folding and collective migration in the intestinal 
 crypt.\n\nThis seminar will be given online via Zoom. Details in attached 
 poster.\n
DTSTART:20220204T160000Z
DTEND:20220204T170000Z
SUMMARY:Online seminar: Mechanobiology of intestinal organoids
URL:/physiology/channels/event/online-seminar-mechanob
 iology-intestinal-organoids-334411
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