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UID:20250721T070303EDT-9156SCN1Kw@132.216.98.100
DTSTAMP:20250721T110303Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at The Neuro and Â鶹ɫÇéƬ Univers
 ity.\n\n\nTo attend in person\, register here\n\nTo watch via vimeo\, clic
 k here\n\n\nKevin Beier\n\nAssociate Professor\, Physiology & Biophysics S
 chool of Medicine\, University of California\, Irvine\n\nHost: wayne.sossi
 n [at] mcgill.ca (Wayne Sossin)\n\nAbstract: Administration of the Zeta In
 hibitory Peptide (ZIP) interferes with memory maintenance and long-term po
 tentiation (LTP). However\, mice lacking its putative target\, the protein
  kinase PKM2\, exhibit normal learning and memory as well as LTP\, making 
 ZIP’s mechanism unclear. Here\, we show that ZIP disrupts LTP by removing 
 surface AMPA receptors through its cationic charge alone. This effect requ
 ires endophilin A2 (endoA2)-mediated endocytosis and is fully blocked by d
 rugs suppressing macropinocytosis. ZIP and other cationic peptides selecti
 vely remove newly inserted AMPAR nanoclusters\, providing a mechanism by w
 hich these peptides erase memories without altering basal synaptic functio
 n. When delivered in vivo\, cationic peptides modulate memories on local a
 nd brain-wide scales and prevent memory loss in a model of traumatic brain
  injury. Our findings uncover a previously unknown synaptic mechanism by w
 hich memories are maintained or lost.\n
DTSTART:20241022T200000Z
DTEND:20241022T210000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Killam Seminar Series: Think Positively: Novel Mechanisms of Modula
 ting Synaptic Plasticity and Implications for Brain Disease
URL:/neuro/channels/event/killam-seminar-series-think-
 positively-novel-mechanisms-modulating-synaptic-plasticity-and-358311
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