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UID:20250821T174427EDT-40047FCFWB@132.216.98.100
DTSTAMP:20250821T214427Z
DESCRIPTION:Zoom link: https://mcgill.zoom.us/j/7468754607\n\nAbstract:\n\n
 The development of smart nanoassemblies self-assembled from well-controlle
 d block copolymers undergoing chemical transition through stimuli-responsi
 ve degradation (SRD) has been extensively explored as an effective platfor
 m for tumor-targeting intracellular drug delivery. Given our significant e
 fforts to synthesize various reduction-responsive systems utilizing disulf
 ide chemistry\, our group has recently focused on the development of an ef
 fective SRD strategy that centers on the design of new intracellular nanoc
 arriers exhibiting dual stimuli responses at dual locations (micellar core
 s and core/corona interfaces). With the focus on cellular endosomal/lysoso
 mal pH = 4.5-5.5 and a tripeptide glutathione\, our approach called dual l
 ocation dual acid/glutathione-responsive degradation (DL-DSRD) offers the 
 versatility in that dual responses to each stimulus can independently regu
 late the release of encapsulated molecules\, and can facilitate synergisti
 c/accelerated release at dual locations.\n\nBio:\n\nDr. John Oh is a Canad
 a Research Chair Tier II and a full professor in the Department of Chemist
 ry and Biochemistry at Concordia University. He earned his PhD degree from
  the University of Toronto in the area of polymer chemistry and materials 
 science. He then completed his NSERC-funded postdoctoral research at Carne
 gie Mellon University. He also experienced industrial R&D at Korea Chemica
 l Company in Korea and Dow Chemical Company in Michigan over 10 years befo
 re Concordia. He has authored and coauthored 119 peer-reviewed publication
 s and 7 invited book chapters and holds 16 international patents. His rese
 arch interests involve the design and processing of macromolecular nanosca
 le materials for drug delivery and cellular imaging as well as self-healab
 le materials.\n
DTSTART:20210223T180000Z
DTEND:20210223T193000Z
SUMMARY:Chemical Society Seminar: John Oh - Dual location dual smart block 
 copolymer nanoassembly/disassembly platform for cancer chemotherapy
URL:/chemistry/channels/event/chemical-society-seminar
 -john-oh-dual-location-dual-smart-block-copolymer-nanoassemblydisassembly-
 327727
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